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RNase A is a high-quality endoribonuclease extracted from bovine pancreas that can specifically degrade single-stranded RNA at the C and U residue positions. The enzyme can cleave the phosphodiester bond between the 5' - ribose on the nucleoside and the phosphate group on the 3' - ribose of the adjacent pyrimidine nucleoside, and products are 3' - pyrimidine mononucleotide or oligonucleotide ending in 3' - pyrimidine nucleotide. It is widely used to remove RNA from DNA samples.