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The Ribo-off rRNA Depletion Kit (H/M/R) is designed to deplete rRNA (including cytoplasmic 28S, 18S, 5S rRNA, and mitochodrial 12S, 5.8S rRNA) from human, mouse, and rat total RNA preparations, while leaving mRNA and other non-coding RNA. This kit is suitable for both intact and degraded RNA samples (i.e. FFPE RNA). The obtained rRNA-depleted RNA can be used for analysis applications of mRNA and non-coding RNA (e.g. lncRNA).