LOGO
Search
Search
Cancel
这是描述信息

Discovery of Novel Leucine Receptor Protein SAR1B Regulating mTORC1 Activity — Revealing New Mechanism of Lung Cancer

  • Time of issue:2021-10-22 09:46

(Summary description)Discovery of Novel Leucine Receptor Protein SAR1B Regulating mTORC1 Activity — Revealing New Mechanism of Lung Cancer

Discovery of Novel Leucine Receptor Protein SAR1B Regulating mTORC1 Activity — Revealing New Mechanism of Lung Cancer

(Summary description)Discovery of Novel Leucine Receptor Protein SAR1B Regulating mTORC1 Activity — Revealing New Mechanism of Lung Cancer

  • Categories:News
  • Author:
  • Origin:
  • Time of issue:2021-10-22 09:46
  • Views:
Information

Discovery of Novel Leucine Receptor Protein SAR1B Regulating mTORC1 Activity — Revealing New Mechanism of Lung Cancer

 

Basic Information & Overview

 

Title: SAR1B senses leucine levels to regulate mTORC1 signalling Periodical: Nature (IF 49.962)

Author & Organization: Joint Corresponding Authors: Professor Ying Liu and Doctor Jie Chen; Joint First Authors: Doctor Jie Chen and Doctoral student Yuhui Ou. Peking University.

Vazyme product: AceQ Universal SYBR qPCR Master Mix (Product No. Q511, SYBR qPCR Mix)

 

 

On July 21, 2021, Ying Lius group (Institute of Molecular Medicine, College of Future Technology, Peking University; Peking-Tsinghua Center for Life Sciences; Beijing Advanced Innovation Center for Genomics) published in Nature a paper entitled: SAR1B senses leucine levels to regulate mTORC1 signalling.

The study reported the mechanism of mTORC1 regulation by a novel leucine receptor protein, SAR1B, and identified a potential role for SAR1B-mTORC1 signaling in human non-small cell lung cancer.

 

 

Vazyme Product Support

 

Vazymes AceQ Universal SYBR qPCR Master Mix (Q511)played a role in the study. The researchers demonstrated that SAR1B senses leucine independently of the other components of COPⅡ by knocking down the genes of SAR1B and other components of COPⅡ separately. In the validation of knockdown efficiency, Q511 was used for all qPCR assays. Q511 is a special premix for qPCR reactions using SYBR Green I chimeric fluorescence method, which is ideal for highly specific and high-sensitivity qPCR reactions. The product contains special ROX Passive Reference Dye, which is suitable for all qPCR instruments. There is no need to adjust the concentration of ROX on different instruments. You only need to add primers and templates when preparing the reaction system to perform amplification.

Vazyme keeps serving customers with high quality products and expects to work together with more researchers, aiming to reach the peak in various fields of life science.

 

 

Q511 Product Information

 

Name:AceQ Universal SYBR qPCR Master Mix  Product No.:Q511

 

Advantages

Universal on all platforms: Special ROX reference dye, suitable for all qPCR instruments, no need to adjust ROX concentration on different instruments

Rigorous hot-start enzyme: AceTaq DNA Polymerase, based on chemical hot-start, provides perfect amplification specificity

Optimized reaction body: patented buffer formula, which minimizes non-specific amplification and primer dimerization, without repeated optimization of conditions

Excellent amplification performance: repeatable and reliable quantitative results to meet the data requirements of high-level magazines

 

Ordering Information

Name

No.

Specification

AceQ Universal SYBR qPCR Master Mix

Q511

500/2,500 rxn(20 μl/rxn)

 

Other High IF Papers Citing Q511

Title

Periodical

IF

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Nature Methods

28.547

Neutrophil Decoys with Antinflammatory and Anti㎡xidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery

Advanced Functional Materials

18.808

Inhibition of Drp1 SUMOylation by ALR protects the liver fromischemia-reperfusion injury

Cell Death and Differentiation

15.828

The histone methyltransferase Setd2 is indispensable for V(D)J recombination

Nature Communications

14.919

 

1. Robert A. Saxton, David M. Sabatini.. mTOR Signaling in Growth, Metabolism, and Disease. Cell 168, 960-976 (2017)2. Bar-Peled, L. et al. A Tumor suppressor complex with GAP activity for the Rag GTPasesthat signal amino acid sufficiency to mTORC1. Science 340, 1100–1106 (2013)3. Wolfson, R. L. et al. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351,43–48 (2016)4. Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R.. COPII and the regulation of protein sorting in mammals. Nat. Cell Biol. 14, 20–28 (2012)

Scan the QR code to read on your phone

The products on this website may not be sold in all countries or regions. Please contact Vazyme or your local distributor for further information.

这是描述信息

Address: Floor 1-3, Building C2, Red Maple Technology Industrial Park, Kechuang Road Economy & Technology Development Zone, Nanjing, China.

Copyright 2015 Vazyme Biotech Co.,Ltd All rights reserved  苏ICP备12014779号-1  Power by: www.300.cn nanjing.300.cn