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HCV Test is in the Middle of a Whirlwind

  • Time of issue:2021-10-18 16:44

(Summary description)The Hepatitis C virus (HCV) has been confirmed before human seeing its particle. In this regard, it is the first virus discovered in human.  

HCV Test is in the Middle of a Whirlwind

(Summary description)The Hepatitis C virus (HCV) has been confirmed before human seeing its particle. In this regard, it is the first virus discovered in human.



 

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  • Time of issue:2021-10-18 16:44
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HCV Test is in the Middle of a Whirlwind

The Hepatitis C virus (HCV) has been confirmed before human seeing its particle. In this regard, it is the first virus discovered in human.

The hepatitis C virus belongs to the genus Hepacivirus, a member of the family Flaviviridae. With its RNA genome, the particles are spherical and the spikes are on the virus envelope. It is difficult for HCV to replicate or exist in isolating cells. The more important thing is that HCV is so variable that the development of anti-HCV drugs or vaccines has been slow to make progress. There is currently no successful vaccine against HCV, so the main measure to prevent HCV is cutting off the transmission route. Besides, timely and effective HCV test methods are important to find and diagnose HCV infection as early as possible.

Nowadays, clinical diagnostic strategies for HCV in China include anti-HCV test (screening test and supplementary test) and HCV RNA test (qualitative nucleic acid test). Generally, after the screening experiment at the beginning, if tested positive, a nucleic acid test should be performed to accurately detect infection. Anti-HCV test includes ELISA, Chemiluminescence test, Colloidal gold rapid test and so on. Nucleic acid test includes transcription-mediated amplification (TMA), RT-PCR, branched DNA (bDNA) technology and real-time polymerase chain reaction (RT-qPCR).

 

1、TMA

Utilizing two enzymes, RNA polymerase and reverse transcriptase, to enable isothermal amplification of the target gene.

How TMA works

 

2、RT-PCR

A technique combining reverse transcription (RT) of RNA and polymerase chain reaction (PCR) for complementary DNA (cDNA).

RT-PCR workflow

 

3、bDNA Amplification Technology

An amplification technology to detect specific nucleotide with the design of probes.

How Branched DNA (bDNA) Technology works

4、RT-qPCR

Using non-specific fluorescent dyes or sequence-specific probes that are labelled with a fluorescent reporter to monitor the amplification of a targeted DNA molecule during the PCR in real time.

 

Recommendations

 

Based on HCV test, Vazyme provides related molecular diagnostic materials and solutions

Vazyme could provide nucleic acid extraction related products and high-sensitivity RT-PCR and RT-qPCR related products, which meet HCV RNA test related requirements. In the meantime, Vazyme could provide total solution and customized service.

 

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